CHRONIC MYELOID LEUKEMIA CBC RESULTS AND CML LEUKEMIA SURVIVAL RATE BY AGE.

 CHRONIC MYELOID LEUKEMIA CBC RESULTS:

A complete blood count (CBC) is a test that measures the number and quality of different types of cells in the blood, including white blood cells, red blood cells, and platelets. In chronic myeloid leukemia (CML), the CBC results will typically show an abnormal increase in the number of white blood cells, specifically granulocytes and monocytes.

The following are some of the typical CBC results that may be seen in CML:

Elevated white blood cell count: In CML, there is an overproduction of white blood cells, which can lead to an elevated white blood cell count. This is typically identified through a CBC test, which measures the number of different types of cells in the blood.

Elevated granulocytes: CML is characterized by an overproduction of granulocytes, which are a type of white blood cell that plays a role in fighting infection. A high percentage of granulocytes in the blood is a sign of CML.

Elevated monocytes: Monocytes are another type of white blood cell that is involved in the immune response. Like granulocytes, monocytes are elevated in CML.

Low red blood cell count: CML can cause anemia, which is a condition characterized by a low red blood cell count. This can lead to symptoms such as fatigue, weakness, and shortness of breath.

Low platelet count: CML can cause a decrease in platelets, which are the cells that help blood to clot. This can lead to easy bruising or bleeding, such as nosebleeds or bleeding gums.

It's worth noting that these results can vary from one patient to another and some may not have elevated white blood cells count, but the presence of Philadelphia chromosome is the key factor in the diagnosis of CML. A CBC test should be done regularly for people with CML to monitor the disease progression and response to treatment.

CML LEUKEMIA SURVIVAL RATE BY AGE:

The survival rate for chronic myeloid leukemia (CML) varies depending on a number of factors, including the stage of the disease, the individual's overall health, and the type of treatment received. However, overall survival rates for CML have improved significantly in recent years due to the development of targeted therapies such as tyrosine kinase inhibitors (TKIs).

According to the American Cancer Society, the 5-year survival rate for CML is around 85%. This means that 85% of people with CML are expected to be alive 5 years after their diagnosis. The 10-year survival rate is around 80%.

Age is also a significant factor in the survival rate for CML. Younger adults have a better prognosis than older adults. For example, the 5-year survival rate for people aged 20-44 is around 90%, while for people aged 65-74 it's around 75%.

It's important to note that these survival rates are based on data from a large group of people and may not reflect the individual's experience. Survival rates are constantly changing due to the ongoing advancements in treatments and therapies.

It's also important to note that CML can be a chronic condition and while it can be managed with medication, it is not curable. However, with proper treatment and monitoring, many people with CML are able to live a normal life.

It's important to consult with a doctor or a healthcare professional for a more accurate survival rate for a particular individual's case. They can take into account all the factors that may influence the rate.

WHAT CAUSES CHRONIC MYELOID LEUKEMIA:

The exact cause of chronic myeloid leukemia (CML) is not fully understood. However, it is believed to be caused by a genetic mutation that occurs in the bone marrow. The mutation causes the overproduction of white blood cells, which leads to the development of CML.

The most common genetic mutation in CML is the Philadelphia chromosome, which is a genetic abnormality that is present in nearly all cases of CML. This chromosome is formed by the translocation of genetic material between chromosomes 9 and 22, which results in the fusion of two genes, BCR and ABL. The BCR-ABL gene fusion creates a protein called BCR-ABL tyrosine kinase, which signals the cells to divide and survive in an uncontrolled manner. This leads to the overproduction of white blood cells and the development of CML.

Other genetic mutations have been identified in a small number of cases of CML, but the Philadelphia chromosome is the most common genetic mutation associated with the disease.

It's worth noting that CML is not contagious and it's not a hereditary disease. The cause of the mutation is not clear, but it's believed to occur spontaneously.

It's important to note that certain environmental and lifestyle factors have not been proven to cause CML, but the disease is more common in older adults. So, it's considered more of an acquired disease than a congenital one.